[12136‐60‐6] Li 2 Se (MW 92.84) InChI = 1S/2Li.Se InChIKey = PEXNRZDEKZDXPZ‐UHFFFAOYSA‐N (nucleophilic agent for synthesis of organic selenides 1, 2). In the previous part of our research, we found that lithium treatment significantly decreased serum Mg and enhanced serum Ca [23]. Environ Res 147:1–7. doi:10.7150/ijms.12429 eCollection 2015, Shine B, McKnight RF, Leaver L, Geddes JR (2015) Long-term effects of lithium on renal, thyroid, and parathyroid function: a retrospective analysis of laboratory data. LiCl provided with drinking water did not alter magnesium in chosen organs (brain, liver, skeletal muscle and cardiac muscle) of rats [31]. Asian Pac J Trop Biomed 4(Suppl 2):S603–S609. doi:10.1371/journal.pone.0147469 eCollection 2016, Zhao XQ, Mitani N, Yamaji N, Shen RF, Ma JF (2010) Involvement of silicon influx transporter OsNIP2;1 in selenite uptake in rice. Psychopharmacology 233:1097–1104. However, other scientists reported the time-dependent lithium’s effect on brain magnesium in fish. PubMed  Generally, little information concerning relationships among these three bioelements can be found in the available literature data. Baldew GS, Mol JG, de Kanter FJ, et al. doi:10.1111/jvim.13922, Chelkeba L, Ahmadi A, Abdollahi M, Najafi A, Ghadimi MH, Mosaed R, Mojtahedzadeh M (2015) The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial. Lithium treatment applied in the current study, although rather short compared to therapy used in humans, resulted in a slight increase in body weight vs. control. But, first of all, a wide range of Li doses, applied in the mentioned study, did not change silicon in the brain [19]. In the other organs, no significant differences among the studied groups were observed. Lithium Triethylborohydride in THF gives a suspension of Li2Se. View the article PDF and any associated supplements and figures for a period of 48 hours. doi:10.1007/s11010-005-5426-5, Vijaimohan K, Mallika J, Shyamala DC (2010) Chemoprotective effect of sobatum against lithium-induced oxidative damage in rats. Se alone was observed. In femoral muscle, selenium significantly increased Ca vs. all the other groups. Other studies also revealed the occurrence of vitamin D disturbances in subjects treated with lithium [25]. Although hypercalcaemia is included into side effects of Li therapy, Zamani et al. One of our previous experiments revealed no effect or increase in tissue Mg in rats receiving the similar Li doses in drinking water [30]. Preparative Methods: reduction of Selenium with Lithium in liquid ammonia … Please check your email for instructions on resetting your password. PubMed Central  The current study revealed that the administration of lithium and/or selenium did not affect silicon in any organ except for the spleen. doi:10.1177/0960327111401049, Nangliya V, Sharma A, Yadav D, Sunder S, Nijhawan S, Mishra S (2015) Study of trace elements in liver cirrhosis patients and their role in prognosis of disease. PubMed  These results suggest that alterations observed in serum do not fully reflect changes of these elements’ homeostasis in all organisms. All the presented results are shown below (see Table 3). Harrari et al. In the kidney, lithium markedly increased Ca vs. control. Zinc was shown to be effective in improving of the disturbances of oxidant parameters, resulted from lithium exposure, in erythrocytes [39] and partially in the liver [40]. A slightly higher dose enhanced Si in the liver and femoral muscle, whereas a lower one depleted the kidney Si level. However, a silicon influx transporter OsNIP2;1 was suggested to be the first transporter of inorganic selenium (selenite form) in different organisms—plants, microorganisms and animals [38]. Lithium side effects. lithium selenidolithium Plant Physiol 153:1871–1877. J Am Chem Soc 133:9506–9515. Arq Bras Endocrinol Metabol 58:619–624. In the current study, calcium was the most affected bioelement in organs by lithium and the prevailing effect was an increase vs. control. doi:10.1007/s12011-014-9952-4, Harrison PJ, Cipriani A, Harmer CJ, Nobre AC, Saunders K, Goodwin GM, Geddes JR (2016) Innovative approaches to bipolar disorder and its treatment. In all the studied organs, magnesium was not disturbed significantly by any used treatment (see Table 4). Crujeiras et al. doi:10.12980/APJTB.4.2014APJTB-2013-0038, Article  As side effects of lithium may considerably influence life condition of patients as well as their compliance, the research on agents alleviating lithium’s negative influence has already been performed. Google Scholar, Wielkoszyński T (2000) Modified, spectrophotometric method of silicon determination in biological material. doi:10.1111/nyas.13048, van Melick EJ, Wilting I, Ziere G, Kok RM, Egberts TC (2014) The influence of lithium on calcium homeostasis in older patients in daily clinical practice. doi:10.1016/S0140-6736(14)61842-0, Hayes JF, Marston L, Walters K, Geddes JR, King M, Osborn DP (2016) Adverse renal, endocrine, hepatic, and metabolic events during maintenance mood stabilizer treatment for bipolar disorder: a population-based cohort study. Google Scholar, Li L, Song H, Zhong L, Yang R, Yang XQ, Jiang KL, Liu BZ (2015) Lithium chloride promotes apoptosis in human leukemia NB4 cells by inhibiting glycogen synthase kinase-3 beta. found a time dependence of lithium’s influence on calcium in fish brain. found no changes of blood calcium in patients with hyperphenylalaninemia, although 25% of them showed depressed selenium [35]. doi:10.1002/gps.4041, Baltaci AK, Sunar F, Mogulkoc R, Acar M, Toy H (2014) The effect of zinc deficiency and zinc supplementation on element levels in the bone tissue of ovariectomized rats: histopathologic changes. Calcium level in the studied organs was considerably influenced. Such observations seem to be important and point to the usefulness of the animal model studies, as lithium therapy is applied in humans and the only possible monitoring of its effect is the determination of blood parameters. Use the link below to share a full-text version of this article with your friends and colleagues. Part of Springer Nature. In the current experiment, the lithium-induced changes of studied parameters were reversed by coadministration of selenium, except for silicon in the spleen. Article  While at the beginning, Ca remained unaltered; after 24 h, a slight decrease compared to control was obtained. doi:10.1021/ja201985s, Aksakal N, Erçetin C, Özçınar B, Aral F, Erbie Y (2015) Lithium-associated primary hyperparathyroidism complicated by nephrogenic diabetes insipidus. Unlimited viewing of the article PDF and any associated supplements and figures. Dilithium selenide. After the next 5 min, the absorption of the obtained samples was read at wavelength 800 nm against the blank prepared as described above with using distilled water instead of tissue homogenates. doi:10.2174/1567205013666160415154701, Tkatcheva V, Poirier D, Chong-Kit R, Furdui VI, Burr C, Leger R, Parmar J, Switzer T, Maedler S, Reiner EJ, Sherry JP, Simmons DBD (2015) Lithium an emerging contaminant: bioavailability, effects on protein expression, and homeostasis disruption in short-term exposure of rainbow trout. Se, both alone and given with Li, did not alter Ca vs. control but caused a significant decrease compared to the Li group. 1). Int J Endocrinol 2015:694023. doi:10.1155/2015/694023, Article  doi:10.1104/pp.110.157867, Malhotra A, Dhawan DK (2008) Zinc improves antioxidative enzymes in red blood cells and hematology in lithium-treated rats. Physical Data: d 2.91 g cm−3; red‐brown solid or milky white crystalline suspension in THF.


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