Process Safety Considerations for the Use of 1 M Borane Tetrahydrofuran Complex Under General Purpose Plant Conditions, Process Safety, GlaxoSmithKline R&D, Collegeville, Pennsylvania 19426, United States, Process Safety, GlaxoSmithKline R&D, Zebulon, North Carolina 27597, United States. NACRES NA.22 Files available from the ACS website may be downloaded for personal use only. Harmful if swallowed. violently with water. 5 publications. However, its safe use within the context of general purpose plant conditions is not discussed in detail. These solutions are used for reductions and hydroboration, reactions that are useful in synthesis of organic compounds. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Find more information about Crossref citation counts. The safe handling of 1 M borane tetrahydrofuran complex (BTHF) in the context of storage and shipping has been well-characterized in literature. Danger! not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information A practical route to this is the oxidation of sodium borohydride with iodine in THF. The Borane-tetrahydrofuran complex, with the CAS registry number 14044-65-6, is also known as (Tetrahydrofuran)borane. Prolonged or repeated skin contact may cause defatting and Borane tetrahydrofuran complex solution 1.0 M in THF CAS Number 14044-65-6. [1], Except where otherwise noted, data are given for materials in their. Potential Health Effects Structure. (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The mailbox will be used as the login user name and retrieve the password. These solutions are used for reductions and hydroboration, reactions that are useful in synthesis of organic compounds. Marek Zaidlewicz, Herbert C. Brown, Santhosh F. Neelamkavil, "Borane–Tetrahydrofuran" Encyclopedia of Reagents for Organic Synthesis, 2008 John Wiley & Sons. Contact with water liberates extremely An enhanced basis of safe operation for using BTHF in general purpose plant was established. "A Simple And Convenient Method For The Oxidation Of Organoboranes Using Sodium Perborate: (+)-isopinocampheol", https://en.wikipedia.org/w/index.php?title=Borane–tetrahydrofuran&oldid=863350344, Creative Commons Attribution-ShareAlike License, This page was last edited on 10 October 2018, at 06:46. Causes skin irritation. This article evaluated the thermal stability of BTHF within the context of general purpose plant equipment at near reflux and explored the diborane evolution–BTHF temperature relationship utilizing reaction calorimetry and headspace mass spectroscopy. You’ve supercharged your research process with ACS and Mendeley! Yi Jin, Junhui Yang, Xiaoliang Feng, Jie Li, Jianguo Xu, Xiaobin Chen, Shuhua Wang, Yanwen Lv, Jiangang Yu. Causes respiratory tract irritation. Headspace MS results for aging studies, calorimetry profile for the destruction of fresh BTHF, and ARC traces of fresh BTHF (PDF). However, its safe use within the context of general purpose plant conditions is not discussed in detail. Skin: May be harmful if inhaled. with 5mmol NaBH4 Structure . The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.oprd.6b00407. [1], The complex is commercially available but can also be generated by the dissolution of diborane in THF. These solutions are used for reductions and hydroboration, reactions that are useful in synthesis of organic compounds. Borane-tetrahydrofuran complex or borane-methyl sulfide complex is used to generate triacyloxyboranes, which can be effectively reacted with various nucleophiles (alkylamines, arylamines, hydrazides, alcohols, phenols) at reflux in toluene to provide the corresponding amides and esters in excellent yield.

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